ITIH1

Name

inter-alpha-trypsin inhibitor heavy chain 1

Type

protein-coding

Position

52,777,559–52,792,068 (+)

Aliases

H1P, IATIH, ITI-HC1, ITIH, SHAP

Ensembl

ENSG00000055957

RefSeq RNA

NM_001166434.3, NM_001166435.2, NM_001166436.2, NM_002215.4

RefSeq protein

NP_001159906.1, NP_001159907.1, NP_001159908.1, NP_002206.2

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

inter-alpha-trypsin inhibitor heavy chain 1

Symbol

ITIH1

Biotype

Protein coding

Organism

Homo sapiens

Location

3:52,777,559-52,792,068

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0