ITIH2
Sign in to saveAlso known as H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.
Gene data
ITIH2- Name
- inter-alpha-trypsin inhibitor heavy chain 2
- Type
- protein-coding
- Aliases
- H2P, ITI-HC2, SHAP
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1668
- exact match
- identifiers.org/ncbigene/3698
- genomic end
- 7791483
- genomic start
- 7703316
- cytogenetic location
- 10p14
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- Further reading
Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.
It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.