ITIH2
Sign in to saveAlso known as H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.
Gene data
ITIH2- Name
- inter-alpha-trypsin inhibitor heavy chain 2
- Type
- protein-coding
- Position
- 7,699,386–7,758,675 (+)
- Aliases
- H2P, ITI-HC2, SHAP
- Ensembl
- ENSG00000151655
- RefSeq RNA
- NM_002216.3
- RefSeq protein
- NP_002207.2
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inter-alpha-trypsin inhibitor heavy chain 2
- Symbol
- ITIH2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:7,699,386-7,758,675
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 1668
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3698
- genomic end
- 7791483
- genomic start
- 7703316
- chromosome
- human chromosome 10
- cytogenetic location
- 10p14
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.
It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.
Excerpted from Wikipedia’s “ITIH2” article, available under the CC BY-SA 4.0 licence.