L-ornithine
Sign in to saveOrnithine is a non-proteinogenic α-amino acid that plays a role in the urea cycle. It is not incorporated into proteins during translation. Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency, a disorder of the urea cycle. The moiety derived from ornithine is called ornithyl.
Research
24,057 papers- Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease.Cell metabolism · 2025
- L-ornithine L-aspartate in acute treatment of severe hepatic encephalopathy: A double-blind randomized controlled trial.Hepatology (Baltimore, Md.) · 2022
- L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism.Neurochemical research · 2020
- Safety assessment of L-ornithine oral intake in healthy subjects: a systematic review.Amino acids · 2025
- Solving doubts about L-ornithine L-aspartate for overt hepatic encephalopathy: Whom and how to treat.Hepatology (Baltimore, Md.) · 2018
via PubMed
Article
9 sectionsContents
- Role in urea cycle
- Other reactions
- Research
- Exercise fatigue
- Weightlifting supplement
- Cirrhosis
- See also
- References
- External links
Ornithine is a non-proteinogenic α-amino acid that plays a role in the urea cycle. It is not incorporated into proteins during translation. Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency, a disorder of the urea cycle. The moiety derived from ornithine is called ornithyl.
==Role in urea cycle== L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central component of the urea cycle, which enables the disposal of excess nitrogen. Ornithine itself is recycled and, in a sense, acts as a catalyst.