لاکتاز

Also known as LCT, lactase-glycosylceramidase, lactase-phlorizin hydrolase-1, lactase-phlorizin hydrolase

Key facts

Enzyme.Name: Glycosylceramidase(Phlorizin hydrolase)
Enzyme.EC_number: 3.2.1.62
Enzyme.CAS_number: 9033-10-7
Enzyme.GO_code: 0017042
Enzyme.image: 1jyn.jpg
Enzyme.width: 270
Enzyme.caption: E. coli lactase tetramer.
Protein.Name: Lactase
Protein.Symbol: LCT
Protein.AltSymbols: LAC; LPH; LPH1
Protein.HGNCid: 6530
Protein.Chromosome: 2
Protein.Arm: q
Protein.Band: 21
Protein.ECnumber: 3.2.1.108
Protein.OMIM: 603202
Protein.EntrezGene: 3938
Protein.RefSeq: NM_002299

via Wikipedia infobox

Protein · UniProt

Lactase/phlorizin hydrolase

Gene: LCT
Organism: Homo sapiens (Human)
Length: 1,927 aa
Molecular mass: 218,587 Da
Evidence: 1: Evidence at protein level

Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:12594539, PubMed:16400612, PubMed:3929764, PubMed:9762914). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:12594539, PubMed:3929764, PubMed:9762914)

Cell membraneDisease variantGlycoproteinGlycosidaseHydrolaseMembraneMultifunctional enzymeProteomics identification

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Swiss-Prot (reviewed) · via UniProt