Skip to content
GeneQ18031928· pop 7· linked from 62 articles

Also known as hTDG, Thymine-DNA glycosylase, thymine DNA glycosylase

protein-coding gene in the species Homo sapiens

Gene data

TDG
Name
thymine DNA glycosylase
Type
protein-coding
Aliases
hTDG

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image
Protein TDG PDB 1wyw.png
Show 5 more facts
HomoloGene ID
2415
genomic end
104382652
genomic start
103965822
cytogenetic location
12q23.3
Sources (4)

via Wikidata · CC0

Available in 7 languages

via Wikidata sitelinks · CC0

Connections

Categories