Also known as hTDG, Thymine-DNA glycosylase, thymine DNA glycosylase
protein-coding gene in the species Homo sapiens
Gene data
TDG- Name
- thymine DNA glycosylase
- Type
- protein-coding
- Aliases
- hTDG
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein TDG PDB 1wyw.png
Show 5 more facts
- HomoloGene ID
- 2415
- exact match
- identifiers.org/ncbigene/6996
- genomic end
- 104382652
- genomic start
- 103965822
- cytogenetic location
- 12q23.3
Sources (4)
via Wikidata · CC0