leflunomide
Sign in to saveLeflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
Key facts
- Drug.verifiedrevid
- 462089809
- Drug.image
- Leflunomide.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Leflunomide ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Arava, Lefumide, Arabloc, others
- Drug.MedlinePlus
- a600032
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Leflunomide
- Drug.pregnancy_AU
- X
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
- AK01
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Article
10 sectionsContents
- Medical use
- Contraindications
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Leflunomide metabolism
- References
- Further reading
Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
right|thumb|Bottle of Leflunomide (Arava) and tablet