File:Leptin.png · Wikimedia Commons · See Wikimedia Commons
Leptin
Sign in to saveAlso known as leptin (murine obesity homolog), leptin (obesity homolog, mouse), obesity factor, LEP, obese protein, obese, mouse, homolog of
organische Verbindung, Naturstoff, Proteohormon, Protein
OverviewAI-generated
Leptin is a human protein encoded by the LEP gene. The molecule consists of 167 amino acids and has a mass of 18,641. It is associated with obesity, diabetes mellitus, and disease variants. Structural features include disulfide bonds, and its three-dimensional structure has been characterized. Evidence for the protein’s existence is established at the protein level.
The protein is cataloged in UniProt under the accession P41159. It is the subject of 197 clinical trials listed on ClinicalTrials.gov. Additionally, the topic is referenced by 474 other encyclopedia articles.
Synthesized by Vinony from 15 facts across 4 sources: Wikidata, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Protein family.Symbol
- Leptin
- Protein family.Name
- Leptin
- Protein family.image
- PDB 1ax8 EBI.jpg
- Protein family.caption
- Structure of the obese protein leptin-E100
- Protein family.Pfam
- PF02024
- Protein family.Pfam_clan
- CL0053
- Protein family.InterPro
- IPR000065
- Protein family.SCOP
- 1ax8
via Wikipedia infobox
Protein · UniProt
Leptin
- Gene
- LEP
- Organism
- Homo sapiens (Human)
- Length
- 167 aa
- Molecular mass
- 18,641 Da
- Evidence
- 1: Evidence at protein level
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:15899045, PubMed:17344214, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
197 registered- COMPLETEDThe Effect of Aerobic Exercise on Selective Biomarkers of Patients With CancerIzmir Bakircay University · NCT07048847
- PHASE2COMPLETEDClinical Evaluation of Polyherbal Coded Formulation Obesecure for Leptin Regulation and Obesity ManagementHafiz Muhammad Asif · NCT04443790
- NARECRUITINGReprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social TrainingBambino Gesù Hospital and Research Institute · NCT06931730
- COMPLETEDEffects of Smoking on Placenta and LactationCelal Bayar University · NCT06456645
- NACOMPLETEDA Crossover Study of the Acute Effects of Olanzapine in Healthy VolunteersMilton S. Hershey Medical Center · NCT00741026
- NARECRUITINGComparison of Two Different Intensity Exercises on Young Women With ObesityAhi Evran University Education and Research Hospital · NCT06610955
Wikidata facts
- Instance of
- protein
Show 6 more facts
- different from
- lectin
- Commons category
- Leptin (obesity protein)
- HomoloGene ID
- 193
- exact match
- purl.uniprot.org/uniprot/P41159
- cell component
- extracellular space
- found in taxon
- Homo sapiens
via Wikidata · CC0
Article · Deutsch
Leptin (von griechisch λεπτός leptós, "dünn") ist ein Proteohormon, das vorwiegend von Fettzellen und Enterozyten im Dünndarm gebildet wird und zur Regulierung des Energiehaushalts beiträgt, indem es das Hungergefühl hemmt, was wiederum die Fettspeicherung in den Fettzellen vermindert. Leptin wirkt auf Zellrezeptoren im Nucleus arcuatus und ventromedialis sowie in anderen Teilen des Hypothalamus und auf dopaminerge Neuronen der Area tegmentalis ventralis und vermittelt so die Nahrungsaufnahme. Obwohl die Regulierung der Fettspeicher als die primäre Funktion von Leptin angesehen wird, spielt es auch bei anderen physiologischen Prozessen eine Rolle, was durch die vielen Syntheseorte außerhalb der Fettzellen und die vielen Zelltypen jenseits der hypothalamischen Zellen, die Leptinrezeptoren besitzen, belegt wird. Viele dieser zusätzlichen Funktionen sind noch nicht vollständig geklärt. Bei Adipositas kommt es zu einer verminderten Empfindlichkeit gegenüber Leptin (ähnlich der Insulinresistenz bei Typ-2-Diabetes), was dazu führt, dass das Sättigungsgefühl trotz hoher Energiespeicher und hoher Leptinspiegel nicht erkannt werden kann.
Abstract from DBpedia / Wikipedia · CC BY-SA