leptin
Sign in to saveLeptin (from Greek λεπτός leptos, "thin" or "light" or "small"), also known as obese protein, is a protein hormone predominantly made by adipocytes (cells of adipose tissue). Its primary role is likely to regulate long-term energy balance.
Key facts
- Protein family.Symbol
- Leptin
- Protein family.Name
- Leptin
- Protein family.image
- PDB 1ax8 EBI.jpg
- Protein family.caption
- Structure of the obese protein leptin-E100
- Protein family.Pfam
- PF02024
- Protein family.Pfam_clan
- CL0053
- Protein family.InterPro
- IPR000065
- Protein family.SCOP
- 1ax8
via Wikipedia infobox
Article
38 sectionsContents
- {{anchor|Effects}}Effects
- Central nervous system
- Hypothalamus
- Circulatory system
- Fetal lung
- Reproductive system
- Ovulatory cycle
- Pregnancy
- Lactation
- Puberty
- Bone
- Immune system
- Location of gene and structure of hormone
- Mutations
- Nonsense
- Frameshift
- Polymorphisms
- Transversion
- Sites of synthesis
- Blood levels
- Physiologic variation
- In specific conditions
- In mutations
- Role in disease
- Obesity
- Role in osteoarthritis with obesity
- Obesity and osteoarthritis
- Leptin and osteoarthritis
- Therapeutic use
- Leptin
- Analog metreleptin
- Research
- History
- Identification of the encoding gene
- Recognition of scientific advances
- See also
- References
- External links
Leptin (from Greek λεπτός leptos, "thin" or "light" or "small"), also known as obese protein, is a protein hormone predominantly made by adipocytes (cells of adipose tissue). Its primary role is likely to regulate long-term energy balance.
As one of the major signals of energy status, leptin levels influence appetite, satiety, and motivated behaviors oriented toward the maintenance of energy reserves (e.g., feeding, foraging behaviors).