LIG4

Name

DNA ligase 4

Type

protein-coding

Position

108,207,439–108,218,373 (−)

Aliases

LIG4S

Ensembl

ENSG00000174405

RefSeq RNA

NM_001098268.2, NM_001330595.2, NM_001352598.2, NM_001352599.2, NM_001352600.2

RefSeq protein

NP_001091738.1, NP_001317524.1, NP_001339527.1, NP_001339528.1, NP_001339529.1

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

DNA ligase 4

Symbol

LIG4

Biotype

Protein coding

Organism

Homo sapiens

Location

13:108,207,439-108,218,373

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein LIG4 PDB 1ik9.png

via Wikidata · CC0