lincosamides
Sign in to savethumb|Lincomycin thumb|Clindamycin (note chlorine atom compared to lincomycin) Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
Research
10,644 papers- Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications.Biochemical pharmacology · 2017
- [Lincosamides].Pathologie-biologie · 1986
- Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.Cold Spring Harbor perspectives in medicine · 2016
- Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications.Advances in applied microbiology · 2004
- An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.Science (New York, N.Y.) · 2024
via PubMed
Article
15 sectionsContents
- Structure
- Synthesis
- Mechanism of action
- Resistance
- Ribosomal methylation
- Target mutation
- Antibiotic efflux
- Drug modification
- Pharmacokinetics
- Clinical use
- Toxicity and interactions
- Lincosamide brand name formulations
- History
- Further reading
- References
thumb|Lincomycin thumb|Clindamycin (note chlorine atom compared to lincomycin) Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
== Structure == Lincosamides consist of a pyrrolidine ring linked to a pyranose moiety (methylthio-lincosamide) via an amide bond. Hydrolysis of lincosamides, specifically lincomycin, splits the molecule into its building blocks of the sugar and proline moieties. Both of these derivatives can conversely be recombined into the drug itself or a derivative.