lorazepam

Also known as Ativan®, Orfidal®, (±)-Lorazepam, Ativan, Lormetazepam, Methyllorazepam, N-Methyllorazepam, O-Chlorooxazepam

thumb|A box of Lorazepam Orion (lorazepam) tablets

OverviewAI-generated

Lorazepam is a chemical compound with the formula C₁₅H₁₀Cl₂N₂O₂. Its IUPAC name is 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one. The molecule has a mass of 320.011933 and a weight of 321.2. It possesses a charge of 0, an xlogp of 2.4, and a tpsa of 61.7. The structure includes 2 hydrogen bond donors and 3 hydrogen bond acceptors.

The defined daily dose for lorazepam is 2.5. It is associated with the MCN code 2933.91.42. The compound has been the subject of 5611 entries in PubMed literature. Additionally, it is referenced by 1,140 other encyclopedia articles.

Synthesized by Vinony from 20 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Drug.legal_US: Schedule IV
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 419619495
Drug.image: Lorazepam.svg
Drug.image_class: skin-invert-image
Drug.width: 150
Drug.image2: Lorazepam ball-and-stick model.png
Drug.image_class2: bg-transparent
Drug.width2: 150
Drug.tradename: Ativan, others
Drug.MedlinePlus: a682053
Drug.DailyMedID: Lorazepam
Drug.pregnancy_AU: C
Drug.dependency_liability: High
Drug.addiction_liability: Moderate
Drug.routes_of_administration: By mouth, intramuscular, intravenous, transdermal
Drug.class: Benzodiazepine

via Wikipedia infobox

Chemical data

Formula: C15H10Cl2N2O2
Molecular weight: 321.2 g/mol
IUPAC name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChIKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
XLogP: 2.4
Polar surface area: 61.7 Å²
H-bond donors: 2
H-bond acceptors: 3
Formal charge: 0

via PubChem

Research

5,611 papers

via PubMed

~31 min read

Encyclopedic overview

24 sections

Contents

Medical uses
Anxiety
Seizures
Sedation
Agitation
Other
Available forms
Adverse effects
Contraindications
Specific groups
Tolerance and dependence
Withdrawal
Interactions
Overdose
Detection in body fluids
Pharmacology
Pharmacokinetics
Pharmacodynamics
History
Society and culture
Recreational use
Legal status
References
External links

thumb|A box of Lorazepam Orion (lorazepam) tablets

Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety (including anxiety disorders), insomnia, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. It is also used during surgery to interfere with memory formation, to sedate those who are being mechanically ventilated, and, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given orally (by mouth), transdermally (on the skin via a topical gel or patch), intravenously (injection into a vein), or intramuscularly (injection into a muscle). When given by injection, onset of effects is between one and thirty minutes and effects last for up to a day.

Excerpted from Wikipedia’s “lorazepam” article, available under the CC BY-SA 4.0 licence.