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Elzasonan
Sign in to saveElzasonan (CP-448,187) is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued, possibly due to poor efficacy. By preferentially blocking 5-HT1B and 5-HT1D autoreceptors, elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus, thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects.
Chemical data
- Formula
- C22H23Cl2N3OS
- Molecular weight
- 448.4 g/mol
- IUPAC name
- (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one
- SMILES
- CN1CCN(CC1)C2=CC=CC=C2/C=C\3/C(=O)N(CCS3)C4=CC(=C(C=C4)Cl)Cl
- InChIKey
- LHYMPSWMHXUWSK-STZFKDTASA-N
- XLogP
- 5.1
- Polar surface area
- 52.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 421.163771
Show 4 more facts
- chemical formula
- C₂₃H₂₃N₃O₅
- canonical SMILES
- CCC1=CC=C(C=C1)OCC2=C(C=CC(=C2)C=CC(=O)C3=NN(C=C3[N+](=O)[O-])C)OC
- isomeric SMILES
- CCC1=CC=C(C=C1)OCC2=C(C=CC(=C2)/C=C/C(=O)C3=NN(C=C3[N+](=O)[O-])C)OC
- Commons category
- Elzasonan
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Elzasonan (CP-448,187) is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued, possibly due to poor efficacy. By preferentially blocking 5-HT1B and 5-HT1D autoreceptors, elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus, thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects.
== See also == GR-127,935 SB-649,915
Excerpted from Wikipedia’s “Elzasonan” article, available under the CC BY-SA 4.0 licence.