LPXN

Also known as LDPL, leupaxin

Leupaxin is a protein that in humans is encoded by the LPXN gene.

In the Vinony graph

Within Vinony's link graph, LPXN is referenced by 3 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 8 Wikipedia language editions.

Gene data

LPXN

Name: leupaxin
Type: protein-coding
Position: 58,526,871–58,578,220 (−)
Aliases: LDPL
Ensembl: ENSG00000110031
RefSeq RNA: NM_001143995.3, NM_001307951.2, NM_004811.3, XM_011545390.3, XM_011545393.4
RefSeq protein: NP_001137467.1, NP_001294880.1, NP_004802.1, XP_011543692.1, XP_011543695.1

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].

via MyGene.info

Gene · Ensembl

leupaxin

Symbol: LPXN
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:58,526,871-58,578,220
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein LPXN PDB 1x3h.png

Show 7 more facts

HomoloGene ID: 3536
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9404
genomic end: 58345693
genomic start: 58294344
chromosome: human chromosome 11
cytogenetic location: 11q12.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Leupaxin is a protein that in humans is encoded by the LPXN gene.

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.

Excerpted from Wikipedia’s “LPXN” article, available under the CC BY-SA 4.0 licence.