File:Malaria_Parasite_Connecting_to_Human_Red_Blood_Cell_(34034143483).jpg · Wikimedia Commons · See Wikimedia Commons

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malaria

Also known as Plasmodium infection, induced malaria, ague, marsh fever

malattia causata da parassiti

OverviewAI-generated

Malaria is an endemic disease classified as a parasitic protozoa infectious disease and vector-borne disease. It is caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale, with Anopheles serving as its natural reservoir. Poverty acts as a contributing factor to the condition. The disease has a minimal incubation period in humans of 7.

Clinical manifestations include intermittent fever, hepatomegaly, anemia, and splenomegaly. Diagnosis involves medical examinations such as blood film analysis, optical microscope usage, and polymerase chain reaction. Health specialties managing the disease include infectious diseases, tropical medicine, and parasitology. Treatments utilize drugs such as chloroquine, (RS)-primaquine, hydroxychloroquine, and mefloquine. Genetic associations involve ABO and ATP2B4.

The condition has been described by sources including the Armenian Soviet Encyclopedia, Brockhaus and Efron Encyclopedic Dictionary, and Encyclopædia Britannica 11th edition. Ronald Ross and Charles Louis Alphonse Laveran are credited as discoverers. Reported statistics indicate 500,000,000 cases and 627,000 deaths, with a disease burden of 216,000,000.

Synthesized by Vinony from 25 facts across 3 sources: Wikidata, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Medical condition.name: Malaria
Medical condition.synonym: Ague, paludism, marsh fever
Medical condition.image: Malaria Parasite Connecting to Human Red Blood Cell (34034143483).jpg
Medical condition.caption: Malaria parasite connecting to a red blood cell
Medical condition.field: Infectious disease
Medical condition.symptoms: Mild malaria: fever, chills, vomiting, headache, diarrhea. Severe malaria: anemia, jaundice, coma
Medical condition.complications: seizures, coma, organ failure, anemia, cerebral malaria
Medical condition.onset: usually 10–15 days post exposure
Medical condition.duration: lifelong if not treated
Medical condition.causes: Plasmodium transmitted by Anopheles mosquitoes
Medical condition.risks: Exposure to mosquitoes in Endemic areas
Medical condition.diagnosis: Examination of the blood, antigen detection tests
Medical condition.prevention: Mosquito nets, insect repellent, mosquito control, prophylactic medication
Medical condition.medication: Antimalarial medication
Medical condition.frequency: 263 million (2023)
Medical condition.deaths: 597,000 (2023)

via Wikipedia infobox

Research

124,011 papers

An Overview of Malaria Transmission Mechanisms, Control, and Modeling.ReviewMedical sciences (Basel, Switzerland) · 2022Savi MKDOI: 10.3390/medsci11010003
Overview of Plasmodium spp. and Animal Models in Malaria Research.ReviewComparative medicine · 2024Gozalo AS, Robinson CK, Holdridge J et al.DOI: 10.30802/AALAS-CM-24-000019
Malaria's modelling problem.Nature · 2023Nordling LDOI: 10.1038/d41586-023-02054-1
Non-falciparum malaria infections in Uganda, does it matter? A review of the published literature.ReviewMalaria journal · 2024Ranjbar M, Tegegn Woldemariam YDOI: 10.1186/s12936-024-05023-9
Extracellular Vesicles in Malaria: Shedding Light on Pathogenic Depths.ReviewACS infectious diseases · 2024Dey S, Mohapatra S, Khokhar M et al.DOI: 10.1021/acsinfecdis.3c00649
The Effect of Malaria on Responses to Unrelated Vaccines in Animals and Humans: A Systematic Review and Meta-Analysis.Parasite immunology · 2024Zirimenya L, Natukunda A, Nassuuna J et al.DOI: 10.1111/pim.13067
Malaria in pregnancy and its potential impact on neurodevelopment in children: a systematic review.Pediatric research · 2025Nema S, Singhal R, Bharti PK et al.DOI: 10.1038/s41390-025-03967-5
Animal Models of Malaria-Associated Acute Kidney Injury.ReviewSeminars in nephrology · 2025Mamudu CO, Polidoro R, Gallego-Delgado JDOI: 10.1016/j.semnephrol.2025.151616

via PubMed

Wikidata facts

Subclass of: disease
Named after: wetland
Image: Histopathology of malaria exoerythrocytic forms in liver 07G0024 lores.jpg
Number of deaths: 627000

Show 26 more facts

has natural reservoir: Anopheles
has cause: Plasmodium knowlesi
has contributing factor: poverty
Commons category: Malaria
discoverer or inventor: Charles Louis Alphonse Laveran
topic's main category: Category:Malaria
medical examination: polymerase chain reaction
NCI Thesaurus ID: C34797
health specialty: parasitology
number of cases: 4114
ICPC 2 ID: A73
drug or therapy used for treatment: atovaquone
disease burden: 216000000
exact match: purl.obolibrary.org/obo/DOID_12365
hashtag: Malaria
symptoms and signs: fever
minimal incubation period in humans: 7
maximal incubation period in humans: 30
disease transmission process: blood transfusion
on focus list of Wikimedia project: WikiProject Medicine
ICD-9-CM: 084.6
WordLift URL: data.medicalrecords.com/medicalrecords/healthwise/malaria
possible treatment: symptomatic treatment
P8168: Álvaro Julio Beyra Luarca
different from: miliaria
maintained by WikiProject: WikiProject South Africa

Sources (15)

via Wikidata · CC0

Article · Italiano

La malaria (detta anche paludismo) è una parassitosi, malattia provocata da parassiti protozoi del genere Plasmodium (Regno Protista, Phylum Apicomplexa, Classe , Ordine ). Fra le varie specie di parassita Plasmodium, quattro sono le più diffuse, ma la più pericolosa è il Plasmodium falciparum, con il più alto tasso di mortalità fra i soggetti infestati. Il serbatoio del parassita è costituito dagli individui infettati in maniera cronica. I vettori sono zanzare del genere Anopheles. La malaria è la più diffusa fra tutte le parassitosi, con il suo quadro clinico di malattia febbrile acuta che si manifesta con segni di gravità diversa a seconda della specie infettante. La sua diffusione attuale non si limita alle aree tropicali dell'America del sud, dell'Africa e dell'Asia, ma interessa sporadicamente anche gli USA e altri paesi industrializzati, in cui casi clinici della malattia possono apparire a seguito di spostamenti di persone che contraggono la malattia in zone in cui essa è endemica. Si pensa che la malaria sia stata tra le cause dell’affermazione della Talassemia minor (e conseguente major) poiché, durante il medioevo, la malaria era molto diffusa in Europa e la mutazione spontanea del gene corrispondente alla talassemia apportava il vantaggio di rendere la riproduzione del patogeno più complessa nel corpo umano. Poiché i sintomi della malaria sono aspecifici, e la diagnosi e il trattamento devono essere tempestivi, la malaria deve essere sospettata in tutti i pazienti con segni febbrili di ritorno dai tropici.

Abstract from DBpedia / Wikipedia · CC BY-SA