MBD4
Sign in to saveAlso known as MED1, methyl-CpG binding domain 4, DNA glycosylase
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
Gene data
MBD4- Name
- methyl-CpG binding domain 4, DNA glycosylase
- Type
- protein-coding
- Aliases
- MED1, TPDS2, UVM1
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].
via MyGene.info
Wikidata facts
- Image
- Protein MBD4 PDB 1ngn.png
Show 5 more facts
- HomoloGene ID
- 2916
- exact match
- identifiers.org/ncbigene/8930
- genomic end
- 129158878
- genomic start
- 129430947
- cytogenetic location
- 3q21.3
Sources (4)
via Wikidata · CC0
~6 min read
Article
12 sectionsContents
- Structure
- Function
- Deaminated bases as targets
- Mutational importance of targets
- Clinical significance in cancer
- Germline mutations of MBD4
- Somatic mutations of MBD4
- Epigenetic silencing
- Response to checkpoint inhibitors
- Interactions
- References
- Further reading
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
==Structure==