MED23

Name

mediator complex subunit 23

Type

protein-coding

Position

131,572,244–131,628,313 (−)

Aliases

ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2

Ensembl

ENSG00000112282

RefSeq RNA

NM_001270521.2, NM_001270522.2, NM_001376517.1, NM_001376518.1, NM_001376519.1

RefSeq protein

NP_001257450.1, NP_001257451.1, NP_001363446.1, NP_001363447.1, NP_001363448.1

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012].

via MyGene.info

Gene · Ensembl

mediator complex subunit 23

Symbol

MED23

Biotype

Protein coding

Organism

Homo sapiens

Location

6:131,572,244-131,628,313

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

The IDRc bound human core Mediator complex - Mediator of RNA polymerase II transcription subunit 23 (2) 8TRH.png

via Wikidata · CC0