CDK8

Name

cyclin dependent kinase 8

Type

protein-coding

Position

26,253,891–26,420,992 (+)

Aliases

IDDHBA, K35

Ensembl

ENSG00000132964

RefSeq RNA

NM_001260.3, NM_001318368.2, NM_001346501.2, XM_011534865.3, XM_047430033.1

RefSeq protein

NP_001251.1, NP_001305297.1, NP_001333430.1, XP_011533167.1, XP_047285989.1

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].

via MyGene.info

Gene · Ensembl

cyclin dependent kinase 8

Symbol

CDK8

Biotype

Protein coding

Organism

Homo sapiens

Location

13:26,253,891-26,420,992

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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