Structure via PubChem · Public domain (PubChem)
meparfynol
Sign in to saveMethylpentynol (also known as methylparafynol, trade names Dormison, Atemorin, Oblivon) is a tertiary pentynol with hypnotic/sedative and anticonvulsant effects and an exceptionally low therapeutic index. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.
Chemical data
- Formula
- C6H10O
- Molecular weight
- 98.14 g/mol
- IUPAC name
- 3-methylpent-1-yn-3-ol
- SMILES
- CCC(C)(C#C)O
- InChIKey
- QXLPXWSKPNOQLE-UHFFFAOYSA-N
- XLogP
- 0.8
- Polar surface area
- 20.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 98.073
Show 3 more facts
- Commons category
- Methylpentynol
- chemical formula
- C₆H₁₀O
- canonical SMILES
- CCC(C)(C#C)O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- Applications
- See also
- References
Methylpentynol (also known as methylparafynol, trade names Dormison, Atemorin, Oblivon) is a tertiary pentynol with hypnotic/sedative and anticonvulsant effects and an exceptionally low therapeutic index. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.
The drug was marketed again in the United States, Europe and elsewhere from 1956 well into the 1960s as a rapid-acting sedative. The drug was quickly overshadowed at that point by benzodiazepines and is no longer sold anywhere.
Excerpted from Wikipedia’s “meparfynol” article, available under the CC BY-SA 4.0 licence.