Microcystin-LR
Sign in to saveMicrocystin-LR (MC-LR) is a toxin produced by cyanobacteria. It is the most toxic of the microcystins.
~16 min read
Encyclopedic overview
26 sectionsContents
- Structure
- Biosynthesis
- Mechanism of toxicity
- Effects
- Human poisonings
- Short-term effects
- Long-term effects
- Animal effects
- Exposure Routes
- Disposition and metabolism
- Disposition
- Metabolism
- Toxicity
- Acute subacute toxicity
- Repeated oral administration
- Carcinogenicity
- Microcystin alone
- Interaction with tumors
- ''In vivo'' animal experiments
- Developmental effects
- Genotoxicity
- ''In vitro'' studies
- Biodegradation
- History
- References
- External links
Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria. It is the most toxic of the microcystins.
==Structure== Microcystins are cyclic heptapeptides. The seven amino acids that are involved in the structure of a microcystin include the unique amino acids ADDA and D-β-methyl-isoaspartate (D-β-Me-isoAsp). Furthermore, microcystins contain two variable residues, which make the differentiation between variants of microcystins. These two variable functionalities are always standard proteinogenic amino acids - In microcystin-LR these are leucine and arginine.
Excerpted from Wikipedia’s “Microcystin-LR” article, available under the CC BY-SA 4.0 licence.