myxoma

A myxoma (New Latin from Greek 'mucus') is a myxoid tumor of primitive connective tissue. It is most commonly found in the heart (and is the most common primary tumor of the heart in adults) but can also occur in other locations.

==Types== Table below: {| class="wikitable" |- !Myxoma !Margin !Vascular pattern ! Cellularity ! Stroma ! Staining characteristics ! Recurrence rate ! Image (see Histology) |- |Cutaneous myxoma or Superficial angiomyxoma |Poor to moderately circumscribed, multilobular |Scattered thin-walled vessels |Moderately cellular, bland spindled and stellate cells, variable inflammatory cell infiltrate |Abundant mucin with clefts. Up to 30% have an associated epithelial component |Vimentin; variable staining with CD34, factor XIIIA, SMA, MSA and S-100 |20–30% |center|100px|Cutaneous Myxoma |- |Intramuscular myxoma |Poorly circumscribed merges with surrounding muscle |Hypovascular variant; hypervascular variant |Hypocellular variant; hypercellular variant; bland spindle cells |Abundant mucin with cystic spaces. Hypercellular variant has strands of collagen |Vimentin; variable staining with actin, desmin, CD34 |None |center|100px |- |Juxta-articular myxoma |Poorly circumscribed infiltrates surrounding tissue |Focally vascular |Focally hypercellular, peripheral spindle cells with occasional atypical cells and mitoses |Abundant mucin, 89% of cases contain cystic spaces lined by fibrin or collagen |Vimentin; variable staining with actin, desmin, CD34 |34% |- |Aggressive angiomyxoma |Infiltrative |Uniformly distributed medium-sized blood vessels often with prominent hyalinization |Low to moderately cellular, evenly distributed round, spindled or stellate cells |Loose myxoid to focally collagenous |Vimentin, desmin, SMA, MSA, estrogen and progesterone receptor |36–72% |- |Angiomyofibroblastoma |Well circumscribed |Abundant thin-walled blood vessels |Alternating hypercellular and hypocellular areas, perivascular condensations of spindled to epithelioid stromal cells |Collagenous to edematous with minimal mucin |Vimentin, desmin, CD34, estrogen and progesterone receptor |No recurrences reported, but rare cases of sarcomatous degeneration |- |Superficial acral fibromyxoma |Pushing to infiltrative |Mild to moderately accentuated vasculature |Moderately cellular, spindle and stellate cells with a storiform to fascicular pattern, variable mast cells |Myxoid to collagenous |CD34, EMA, CD99 |Recurrence rare and primarily for incompletely excised lesions |- |Neurothekeoma (Nerve sheath myxoma) |Well circumscribed, multilobular |Hypovascular |Moderately cellular, spindled cells in fascicles and whorls |Nests of cells separated by collagenous bundles |S-100, EMA |47% if incompletely excised |center|100px |} 1.SMA, smooth muscle actin. 2.MSA, muscle-specific actin. 3.EMA, epithelial membrane antigen.