NDRG1
Sign in to saveAlso known as CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.
Gene data
NDRG1- Name
- N-myc downstream regulated 1
- Type
- protein-coding
- Position
- 133,237,175–133,302,022 (−)
- Aliases
- CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42
- Ensembl
- ENSG00000104419
- RefSeq RNA
- NM_001135242.2, NM_001258432.2, NM_001258433.2, NM_001374844.1, NM_001374845.1
- RefSeq protein
- NP_001128714.1, NP_001245361.1, NP_001245362.1, NP_001361773.1, NP_001361774.1
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
N-myc downstream regulated 1
- Symbol
- NDRG1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:133,237,171-133,302,022
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55953
- exact match
- identifiers.org/ncbigene/10397
- genomic end
- 134314265
- genomic start
- 133237175
- cytogenetic location
- 8q24.22
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Gene
- Role in cancer
- Functions in DNA repair and aging
- Role in immune system
- References
- Further reading
- External links
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D.