TOP1
Sign in to saveAlso known as TOPI, topoisomerase (DNA) I, DNA topoisomerase I
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.
Gene data
TOP1- Name
- DNA topoisomerase I
- Type
- protein-coding
- Position
- 41,028,815–41,124,487 (+)
- Aliases
- TOPI
- Ensembl
- ENSG00000198900
- RefSeq RNA
- NM_003286.4
- RefSeq protein
- NP_003277.1
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DNA topoisomerase I
- Symbol
- TOP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:41,028,815-41,124,487
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TOP1 PDB 1a31.png
Show 8 more facts
- HomoloGene ID
- 2467
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7150
- genomic end
- 39753127
- genomic start
- 41028822
- chromosome
- human chromosome 20
- cytogenetic location
- 20q12
- expressed in
- monocyte
Sources (3)
via Wikidata · CC0
~7 min read
Encyclopedic overview
10 sectionsContents
- Function
- Mechanism
- Inhibition
- Cancer
- Synthetic lethality
- DNA repair
- Interactions
- See also
- References
- External links
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.
== Function ==
Excerpted from Wikipedia’s “TOP1” article, available under the CC BY-SA 4.0 licence.