TOP1

Also known as TOPI, topoisomerase (DNA) I, DNA topoisomerase I

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.

Gene data

TOP1

Name: DNA topoisomerase I
Type: protein-coding
Aliases: TOPI

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

DNA topoisomerase I

Symbol: TOP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:41,028,815-41,124,487
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TOP1 PDB 1a31.png

Show 5 more facts

HomoloGene ID: 2467
exact match: identifiers.org/ncbigene/7150
genomic end: 39753127
genomic start: 41028822
cytogenetic location: 20q12

Sources (3)

via Wikidata · CC0

~7 min read

Article

10 sections

Contents

Function
Mechanism
Inhibition
Cancer
Synthetic lethality
DNA repair
Interactions
See also
References
External links

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.

== Function ==