NEDD4

Also known as NEDD4-1, RPF1, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, NEDD4 E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene.

Gene data

NEDD4

Name: NEDD4 E3 ubiquitin protein ligase
Type: protein-coding
Position: 55,826,917–55,993,660 (−)
Aliases: NEDD4-1, RPF1
Ensembl: ENSG00000069869
RefSeq RNA: NM_001284338.2, NM_001284339.1, NM_001284340.1, NM_001329212.2, NM_006154.4
RefSeq protein: NP_001271267.1, NP_001271268.1, NP_001271269.1, NP_001316141.1, NP_006145.2

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016].

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Endocytosis - Homo sapiens (human)Tight junction - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)ISG15 antiviral mechanism Antimicrobial mechanism of IFN-stimulated genes Signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling Cytokine Signaling in Immune system

via MyGene.info

Gene · Ensembl

NEDD4 E3 ubiquitin protein ligase

Symbol: NEDD4
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:55,826,917-55,993,660
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: NEDD4 HECT domain structure from PDB ID 2XBF.png

Show 5 more facts

HomoloGene ID: 136740
exact match: identifiers.org/ncbigene/4734
genomic end: 55993660
genomic start: 56119120
cytogenetic location: 15q21.3

Sources (6)

via Wikidata · CC0

~7 min read

Article

9 sections

Contents

Structure
Expression
Function
Regulation
Physiological significance
Viral budding
Notes
References
External links

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene.

NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. NEDD4 is, in eukaryotes, a highly conserved gene, and the founding member of the NEDD4 family of E3 HECT ubiquitin ligases, which in humans consists of 9 members: NEDD4 (the core topic of this article) NEDD4-2 (or NEDD4L) ITCH SMURF1 SMURF2 WWP1 WWP2 NEDL1 (HECW1) NEDDL2 (HECW2)].