SGK1

Also known as SGK, serum/glucocorticoid regulated kinase 1

Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.

In the Vinony graph

Within Vinony's link graph, SGK1 is referenced by 13 other articles, and connects out to Q180686, cytokine and glucocorticoid.

It sits within the topics Genes on human chromosome 6 and Molecular neuroscience.

Its subject is documented across 8 Wikipedia language editions.

Gene data

SGK1

Name: serum/glucocorticoid regulated kinase 1
Type: protein-coding
Position: 134,169,248–134,318,117 (−)
Aliases: SGK
Ensembl: ENSG00000118515
RefSeq RNA: NM_001143676.3, NM_001143677.2, NM_001143678.2, NM_001291995.2, NM_005627.4
RefSeq protein: NP_001137148.1, NP_001137149.1, NP_001137150.1, NP_001278924.1, NP_005618.2

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

Pathways

FoxO signaling pathway - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Aldosterone-regulated sodium reabsorption - Homo sapiens (human)PIP3 activates AKT signaling Signal Transduction Signaling by NTRKs Signaling by NTRK1 (TRKA)Nuclear Events (kinase and transcription factor activation)Generic Transcription Pathway

via MyGene.info

Gene · Ensembl

serum/glucocorticoid regulated kinase 1

Symbol: SGK1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:134,169,248-134,318,117
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SGK1 PDB 2R5T.png

Show 5 more facts

HomoloGene ID: 48364
exact match: identifiers.org/ncbigene/6446
genomic end: 134639250
genomic start: 134169248
cytogenetic location: 6q23.2

Sources (7)

via Wikidata · CC0

~13 min read

Encyclopedic overview

19 sections

Contents

Function
Ion channel and transporter regulation
Regulation of cell volume
Dehydration
Cell proliferation and apoptosis
Memory formation
Long-term potentiation
Transcription
Metabolism
Kidney
Gastrointestinal
Cardiovascular
Clinical significance
Role in neuronal disease
Huntingtin
Other neuronal diseases
Interactions
References
External links

Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.

SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids. The kinase is activated by insulin and growth factors via phosphatidylinositide-3-kinase, phosphoinositide-dependent protein kinase PDPK1 and mammalian target of rapamycin mTORC2. It has been shown to "regulate several enzymes and transcription factors; SGK1 contributes to the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation and apoptosis". SGK1 increases the protein abundance and/or activity of a variety of ion channel, carriers, and the Na+/K+-ATPase. Over the past few years, there has been increasing evidence that SGK1 expression is regulated during both discrete developmental stages and pathological conditions such as hypertension, diabetic neuropathy, ischemia, trauma, and neurodegenerative diseases.

Excerpted from Wikipedia’s “SGK1” article, available under the CC BY-SA 4.0 licence.