NEIL3
Sign in to saveAlso known as FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.
Gene data
NEIL3- Name
- nei like DNA glycosylase 3
- Type
- protein-coding
- Position
- 177,309,811–177,363,082 (+)
- Aliases
- FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
- Ensembl
- ENSG00000109674
- RefSeq RNA
- NM_018248.3, XM_047415894.1, XM_054350387.1
- RefSeq protein
- NP_060718.3, XP_047271850.1, XP_054206362.1
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
nei like DNA glycosylase 3
- Symbol
- NEIL3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:177,309,811-177,363,082
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10094
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55247
- genomic end
- 177362936
- genomic start
- 177309874
- chromosome
- human chromosome 4
- cytogenetic location
- 4q34.3
- expressed in
- rectum
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
Excerpted from Wikipedia’s “NEIL3” article, available under the CC BY-SA 4.0 licence.