NEIL1

Also known as FPG1, NEI1, hFPG1, nei like DNA glycosylase 1

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

In the Vinony graph

Vinony's link graph records 27 inbound references to NEIL1, and connects out to PubMed, Ensembl genome database project and cancer.

It is catalogued under topics including Genes on human chromosome 15, Human proteins and Unflagged free DOI.

Vinony links it to 5 Wikipedia language editions.

Gene data

NEIL1

Name: nei like DNA glycosylase 1
Type: protein-coding
Position: 75,346,878–75,357,115 (+)
Aliases: FPG1, NEI1, hFPG1
Ensembl: ENSG00000140398
RefSeq RNA: NM_001256552.1, NM_001352519.2, NM_001352520.2, NM_024608.4, NR_046311.2
RefSeq protein: NP_001243481.1, NP_001339448.1, NP_001339449.1, NP_078884.2

This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].

Pathways

Base excision repair - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Disease APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Base Excision Repair DNA Repair Depyrimidination Base-Excision Repair, AP Site Formation Resolution of Abasic Sites (AP sites)

via MyGene.info

Gene · Ensembl

nei like DNA glycosylase 1

Symbol: NEIL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:75,346,878-75,357,115
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NEIL1 PDB 1tdh.png

Show 8 more facts

HomoloGene ID: 11616
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79661
genomic end: 75357115
genomic start: 75639296
chromosome: human chromosome 15
cytogenetic location: 15q24.2
expressed in: anterior pituitary

Sources (4)

via Wikidata · CC0

~4 min read

Encyclopedic overview

7 sections

Contents

Targets
Deficiency in cancer
Memory retention
Stroke prevention
See also
References
Further reading

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species (ROS) and introducing a DNA strand break via the associated lyase reaction.

Excerpted from Wikipedia’s “NEIL1” article, available under the CC BY-SA 4.0 licence.