Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
via MyGene.info
Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species (ROS) and introducing a DNA strand break via the associated lyase reaction.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).