Structure via PubChem · Public domain (PubChem)
nelfinavir
Sign in to saveAlso known as Viracept
Nelfinavir, sold under the brand name Viracept, is an antiretroviral medication used in the treatment of HIV/AIDS. Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and, like other PIs, it is almost always used in combination with other antiretroviral drugs.
Chemical data
- Formula
- C32H45N3O4S
- Molecular weight
- 567.8 g/mol
- IUPAC name
- (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
- SMILES
- CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
- InChIKey
- QAGYKUNXZHXKMR-HKWSIXNMSA-N
- XLogP
- 5.7
- Polar surface area
- 127 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
2,024 papers- Nelfinavir.Drugs · 1997
- Nelfinavir mesylate.Expert opinion on pharmacotherapy · 2000
- Nelfinavir mesylate: a protease inhibitor.The Annals of pharmacotherapy · 1999
- Nelfinavir: a review of its use in the management of HIV infection.Drugs · 2005
- Nelfinavir. A review of its therapeutic efficacy in HIV infection.Drugs · 1998
via PubMed
Wikidata facts
- Mass
- 567.313
- Manufacturer
- Pfizer
- Has use
- medication
Show 9 more facts
- chemical formula
- C₃₂H₄₅N₃O₄S
- significant drug interaction
- rifapentine
- medical condition treated
- HIV infection
- canonical SMILES
- CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
- isomeric SMILES
- CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
- World Health Organisation international non-proprietary name
- nelfinavir
- defined daily dose
- 2.25
- Commons category
- Nelfinavir
- subject has role
- protease inhibitor
via Wikidata · CC0
~6 min read
Encyclopedic overview
11 sectionsContents
- Toxicity
- Other bioactivity
- Antiviral
- Anti-virulence activity
- Interactions
- Pharmacology
- Mechanism of action
- History
- Research
- References
- Further reading
Nelfinavir, sold under the brand name Viracept, is an antiretroviral medication used in the treatment of HIV/AIDS. Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and, like other PIs, it is almost always used in combination with other antiretroviral drugs.
Nelfinavir is an orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki = 2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Excerpted from Wikipedia’s “nelfinavir” article, available under the CC BY-SA 4.0 licence.