indinavir
Sign in to saveIndinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from functioning normally. Consequently, HIV viruses cannot reproduce, causing a decrease in the viral load. Commercially sold indinavir is indinavir anhydrous, which is indinavir with an additional amine in the hydroxyethylene backbone. This enhances its solubility and oral bioavailability, making it easier for users to intak
Article
13 sectionsContents
- Medical uses
- Viral resistance
- Side effects
- Chemical properties
- History
- Clinical trials
- Study 035
- ACTG 320
- Controversy
- Supply
- Distribution
- Price
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 477168143 | IUPAC_name = (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide | image = Indinavir structure.svg | image_class = skin-invert-image | width = 251 | image2 = Indinavir ball-and-stick.png | image_class2 = bg-transparent
| tradename = Crixivan | Drugs.com = | MedlinePlus = a696028 | licence_US = Indinavir | legal_status = | routes_of_administration = Oral