neuroligin
Sign in to saveAlso known as Nlgn, IPR000460, neuroligins
thumb|right|350px|Neurolign and neurexin "handshake"
Research
1,261 papers- Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.Nature communications · 2024
- Neuroligin-2 as a central organizer of inhibitory synapses in health and disease.Science signaling · 2020
- Modulation of Trans-Synaptic Neurexin-Neuroligin Interaction in Pathological Pain.Cells · 2022
- Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses.Biological psychiatry · 2024
- Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction.Frontiers in molecular neuroscience · 2021
via PubMed
Wikidata facts
- Instance of
- protein family
- Subclass of
- protein
Show 1 more fact
- physically interacts with
- neurexin family
Sources (2)
via Wikidata · CC0
~11 min read
Encyclopedic overview
11 sectionsContents
- Structure
- Genetics
- Expression
- Alternative splicing
- Activity with neurexin
- Synapse formation
- Clinical significance
- NLGN3 mutations
- NLGN4 mutations
- See also
- References
thumb|right|350px|Neurolign and neurexin "handshake"
Neuroligin (NLGN), a type I membrane protein, is a cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons. Neuroligins act as ligands for β-neurexins, which are cell adhesion proteins located presynaptically. Neuroligin and β-neurexin "shake hands", resulting in the connection between two neurons and the production of a synapse. Neuroligins also affect the properties of neural networks by specifying synaptic functions, and they mediate signalling by recruiting and stabilizing key synaptic components. Neuroligins interact with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures. Additionally, neuroligins are expressed in human peripheral tissues and have been found to play a role in angiogenesis. In humans, alterations in genes encoding neuroligins are implicated in autism and other cognitive disorders. Antibodies in a mother from previous male pregnancies against neuroligin 4 from the Y chromosome increase the probability of homosexuality in male offspring.
Excerpted from Wikipedia’s “neuroligin” article, available under the CC BY-SA 4.0 licence.