NRP1

Name

neuropilin 1

Type

protein-coding

Position

33,177,492–33,336,262 (−)

Aliases

BDCA4, CD304, NP1, NRP, VEGF165R

Ensembl

ENSG00000099250

RefSeq RNA

NM_001024628.3, NM_001024629.3, NM_001244972.2, NM_001244973.2, NM_001330068.2

RefSeq protein

NP_001019799.2, NP_001019800.2, NP_001231901.2, NP_001231902.2, NP_001316997.2

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020].

via MyGene.info

Gene · Ensembl

neuropilin 1

Symbol

NRP1

Biotype

Protein coding

Organism

Homo sapiens

Location

10:33,177,492-33,336,262

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein NRP1 PDB 1kex.png

via Wikidata · CC0