angiostatin
Sign in to saveAngiostatin is a naturally occurring protein found in several animal species, including humans. It is an endogenous angiogenesis inhibitor (i.e., it blocks the growth of new blood vessels). Clinical trials have been undertaken for its use in anticancer therapy.
Research
1,037 papers- Angiostatin.Seminars in thrombosis and hemostasis · 2004
- Angiostatin.Cancer treatment and research · 2005
- Angiostatin: a promising therapeutic target for atopic dermatitis.Archives of dermatological research · 2025
- Angiostatin and angiostatin-related proteins.Cancer metastasis reviews · 2000
- Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.Journal of thrombosis and haemostasis : JTH · 2025
via PubMed
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Encyclopedic overview
5 sectionsContents
- Structure
- Generation
- Biological activity
- References
- External links
Angiostatin is a naturally occurring protein found in several animal species, including humans. It is an endogenous angiogenesis inhibitor (i.e., it blocks the growth of new blood vessels). Clinical trials have been undertaken for its use in anticancer therapy.
==Structure== Angiostatin is a 38 kDa fragment of a larger protein, plasmin (itself a fragment of plasminogen) enclosing three to five contiguous kringle modules. Each module contains two small beta sheets and three disulfide bonds.
Excerpted from Wikipedia’s “angiostatin” article, available under the CC BY-SA 4.0 licence.