TNKS
Sign in to saveAlso known as ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.
Gene data
TNKS- Name
- tankyrase
- Type
- protein-coding
- Position
- 9,555,906–9,782,346 (+)
- Aliases
- ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
- Ensembl
- ENSG00000285372
- RefSeq RNA
- NM_003747.3, XM_011543845.4, XM_011543846.4, XM_054332269.1, XM_054332270.1
- RefSeq protein
- NP_003738.2, XP_011542147.1, XP_011542148.1, XP_054188244.1, XP_054188245.1
Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tankyrase
- Symbol
- TNKS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:9,555,906-9,782,346
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNKS PDB 2rf5.png
Show 8 more facts
- HomoloGene ID
- 18405
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8658
- genomic start
- 9555912
- chromosome
- human chromosome 8
- genomic end
- 9639856
- cytogenetic location
- 8p23.1
- expressed in
- tibia
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Description
- Protein interactions
- References
- Further reading
Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.
==Description== Source:
Excerpted from Wikipedia’s “TNKS” article, available under the CC BY-SA 4.0 licence.