NUMB
Sign in to saveAlso known as C14orf41, S171, c14_5527, NUMB, endocytic adaptor protein, NUMB endocytic adaptor protein
protein-coding gene in the species Homo sapiens
Gene data
NUMB- Name
- NUMB endocytic adaptor protein
- Type
- protein-coding
- Position
- 73,274,146–73,466,167 (−)
- Aliases
- C14orf41, S171, c14_5527
- Ensembl
- ENSG00000133961
- RefSeq RNA
- NM_001005743.2, NM_001005744.2, NM_001005745.2, NM_001320114.2, NM_003744.6
- RefSeq protein
- NP_001005743.1, NP_001005744.1, NP_001005745.1, NP_001307043.1, NP_003735.3
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NUMB endocytic adaptor protein
- Symbol
- NUMB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:73,274,146-73,466,167
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein NUMB PDB 1wj1.png
Show 10 more facts
- HomoloGene ID
- 2775
- genetic association
- coronary artery disease
- chromosome
- human chromosome 14
- cytogenetic location
- 14q24.2-q24.3
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8650
- genomic end
- 73458617
- genomic start
- 73741815
- different from
- Numb
- expressed in
- sural nerve
via Wikidata · CC0