Structure via PubChem · Public domain (PubChem)
امبرابولین
Sign in to saveAlso known as Ombrabulin
Ombrabulin was an experimental drug candidate discovered by Ajinomoto and further developed by Sanofi-Aventis. Ombrabulin is a combretastatin A-4 derivative that exerts its antitumor effect by disrupting the formation of blood vessels needed for tumor growth.
Chemical data
- Formula
- C21H26N2O6
- Molecular weight
- 402.4 g/mol
- IUPAC name
- (2S)-2-amino-3-hydroxy-N-[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide
- SMILES
- COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)NC(=O)[C@H](CO)N
- InChIKey
- IXWNTLSTOZFSCM-YVACAVLKSA-N
- XLogP
- 2.2
- Polar surface area
- 112 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- neoplasm, sarcoma, non-small cell lung carcinoma, ovarian cancer
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 402.179
Show 3 more facts
- chemical formula
- C₂₁H₂₆N₂O₆
- isomeric SMILES
- COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)NC(=O)[C@H](CO)N
- canonical SMILES
- COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)NC(=O)C(CO)N
Sources (2)
via Wikidata · CC0