(R)-(-)-combretastatin

Also known as combretastatin

Combretastatin is a dihydrostilbenoid found in Combretum afrum.

Research

47 papers

(Z)-5-(3,4,5-Tri-meth-oxy-styr-yl)-2,3-di-hydro-thieno[3,4-b][1,4]dioxine.Acta crystallographica. Section E, Structure reports online · 2014
Domino Semipinacol/Iterative Aldol/Iso-Nazarov Cyclization to Triaryl-cyclopentenone: Enantioselective Synthesis of Combretastatin A-4 Analogues.Organic letters · 2022
Intravoxel Incoherent Motion Diffusion-weighted MRI Assessing the Effect of the Vascular Disrupting Agent CA4P on VX2 Liver Tumors in Rabbits.Current medical imaging · 2024
Quantitative Evaluation of Combretastatin A4 Phosphate Early Efficacy in a Tumor Model with Dynamic Contrast-Enhanced Ultrasound.Ultrasound in medicine & biology · 2018
Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012

via PubMed

Article

8 sections

Contents

As a class
Natural combretastatins
Biological function
In the plants that make it
In mammalian tumours
Chemical synthesis
Clinical studies
References

Combretastatin is a dihydrostilbenoid found in Combretum afrum.

== As a class == Combretastatins are a class of natural phenols. A variety of different natural combretastatin molecules are present in the bark of C. afrum, commonly known as South African Bush Willow. Despite having a similar name, combretastatins are unrelated to statins, a family of cholesterol lowering drugs.