organ-on-a-chip
An organ-on-a-chip (OOC) is a multi-channel 3D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context. By acting as a more sophisticated in vitro approximation of complex tissues than standard cell culture, they provide the potential as an alternative to
Research
3,472 papers- Organ-on-a-chip meets artificial intelligence in drug evaluation.Theranostics · 2023
- A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications.Biosensors · 2024
- Engineering Organ-on-a-Chip Systems for Vascular Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2023
- Organ-On-A-Chip: An Emerging Research Platform.Organogenesis · 2023
- Organ-on-a-chip: future of female reproductive pathophysiological models.Journal of nanobiotechnology · 2024
via PubMed
Article
18 sectionsContents
- Lab-on-chip
- Transitioning from 3D cell-culture models to OOCs
- Organs
- Brain
- Gut
- Lung
- Heart
- Kidney
- Liver
- Prostate
- Blood vessel
- Skin
- Endometrium
- Human-on-a-chip
- Replacing animal testing
- See also
- References
- External links
An organ-on-a-chip (OOC) is a multi-channel 3D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context. By acting as a more sophisticated in vitro approximation of complex tissues than standard cell culture, they provide the potential as an alternative to animal models for drug development and toxin testing.
Although multiple publications claim to have translated organ functions onto this interface, the development of these microfluidic applications is still in its infancy. Organs-on-chips vary in design and approach between different researchers. Organs that have been simulated by microfluidic devices include brain, lung, heart, kidney, liver, prostate, vessel (artery), skin, bone, cartilage and more.