
Also known as OOC, Microphysiological System, Microphysiological Systems
An organ-on-a-chip (OOC) is a multi-channel 3D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context. By acting as a more sophisticated in vitro approximation of complex tissues than standard cell culture, they provide the potential as an alternative to
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器官晶片(英語:organ-on-a-chip, OOC) ,是一种多通道3D微流控晶片,以细胞培养,模擬器官或系统的活动、力学和生理反应,也是一种人工器官。 它是一个重要的生物医学工程的研究主题。芯片上的实验室(LOCs)和细胞生物学的融合允许在特定器官的背景下研究人类生理学,引入体外多细胞人类生物体的新模型。有望在未来改变在药物开发和毒理测试中对动物的需求。 尽管有多份出版物声称已将器官功能转化到这个器官芯片上,但这些应用仍处于起步阶段。芯片上的器官在不同的研究者之间的设计和方法有很多不同。因此,这些系统的验证和优化将是一个漫长的过程。已经被器官芯片模拟的器官包括大脑、肺、心脏、肾、肝、前列腺、血管(动脉)、皮肤、骨骼、软骨等。
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).