pancreatic lipase
Sign in to saveAlso known as pancreatic triacylglycerol lipase, triacylglycerol acylhydrolase, PNLIP, triacylglycerol lipase
mammalian protein found in Homo sapiens
Protein · UniProt
Pancreatic triacylglycerol lipase
- Gene
- PNLIP
- Organism
- Homo sapiens (Human)
- Length
- 465 aa
- Molecular mass
- 51,157 Da
- Evidence
- 1: Evidence at protein level
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones
3D-structureCalciumDisease variantDisulfide bondGlycoproteinHydrolaseLipid degradationLipid metabolism
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
20 registered- UNKNOWNSerum Parameter Prior and After EUS-guided Fine Needle Aspiration of the PancreasHelios Albert-Schweitzer-Klinik Northeim · NCT02397993
- PHASE2COMPLETEDEfficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic InsufficiencySwedish Orphan Biovitrum · NCT00743483
- COMPLETEDPancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult PatientsShanghai 10th People's Hospital · NCT01753024
- PHASE2NOT_YET_RECRUITINGA Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.Aimmune Nestlé Health Science US R&D, LLC · NCT07559175
- PHASE4ENROLLING_BY_INVITATIONEvaluating RELiZORB Use for the Treatment of Feeding Intolerance in Adults With Moderate to Severe Acute PancreatitisNorthwell Health · NCT07583342
- PHASE3COMPLETEDProphylaxis Against Post-Endoscopic Retrograde Cholangio-Pancreatography Pancreatitis.Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo · NCT07599605
Wikidata facts
- Instance of
- protein
- Image
- Pancreatic lipase–colipase complex with inhibitor 1LPB.png
Show 6 more facts
- found in taxon
- Homo sapiens
- cell component
- extracellular space
- exact match
- purl.uniprot.org/uniprot/P16233
- physically interacts with
- orlistat
- EC enzyme number
- 3.1.1.3
- Commons category
- Pancreatic lipase
via Wikidata · CC0