PAPSS2
Sign in to saveAlso known as ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
'''Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2' is an enzyme that in humans is encoded by the PAPSS2'' gene.
Gene data
PAPSS2- Name
- 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Type
- protein-coding
- Position
- 87,659,613–87,747,708 (+)
- Aliases
- ATPSK2, BCYM4, SK2
- Ensembl
- ENSG00000198682
- RefSeq RNA
- NM_001015880.2, NM_004670.4
- RefSeq protein
- NP_001015880.1, NP_004661.2
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Symbol
- PAPSS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:87,659,613-87,747,708
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
'''Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2' is an enzyme that in humans is encoded by the PAPSS2'' gene.
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Excerpted from Wikipedia’s “PAPSS2” article, available under the CC BY-SA 4.0 licence.