Arylsulfatase B
Sign in to saveAlso known as ARSB, G4S, N-acetylgalactosamine-4-sulfatase
mammalian protein found in Homo sapiens
Protein · UniProt
Arylsulfatase B
- Gene
- ARSB
- Organism
- Homo sapiens (Human)
- Length
- 533 aa
- Molecular mass
- 59,687 Da
- Evidence
- 1: Evidence at protein level
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity)
3D-structureAlternative splicingCalciumDirect protein sequencingDisease variantDisulfide bondGlycoproteinHydrolase
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
5 registered- PHASE1/PHASE2COMPLETEDGene Therapy in Patients With Mucopolysaccharidosis DiseaseFondazione Telethon · NCT03173521
- PHASE2COMPLETEDOpen-Label Study of Efficacy and Safety of Recombinant Human N-acetylgalactosamine 4-sulfatase in Patients With MPS VIBioMarin Pharmaceutical · NCT00048711
- PHASE1COMPLETEDStudy of Recombinant Human N-Acetylgalactosamine 4-Sulfatase in Patients With MPS VIBioMarin Pharmaceutical · NCT00048620
- PHASE3COMPLETEDStudy of rhASB in Patients With Mucopolysaccharidosis VIBioMarin Pharmaceutical · NCT00104234
- PHASE3COMPLETEDStudy of Recombinant Human N-acetylgalactosamine 4-sulfatase (rhASB) in Patients With MPS VIBioMarin Pharmaceutical · NCT00067470
Wikidata facts
Show 3 more facts
- found in taxon
- Homo sapiens
- cell component
- extracellular exosome
- Commons category
- Arylsulfatase B (4-sulfatase)
Sources (3)
via Wikidata · CC0