beta-glucuronidase
Sign in to saveAlso known as glucuronidase, beta-D-glucuronoside glucuronosohydrolase, ketodase, exo-beta-D-glucuronidase, beta-glucuronide glucuronohydrolase
β-Glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates. Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate. Human β-glucuronidase is located in the lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present in breast milk, which contribut
Research
23,961 papers- Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism.Gut microbes · 2023
- Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.European journal of medicinal chemistry · 2020
- Recent advances of sensing strategies for the detection of β-glucuronidase activity.Analytical and bioanalytical chemistry · 2022
- [beta-Glucuronidase].Nihon rinsho. Japanese journal of clinical medicine · 1995
- Beta-Glucuronidase.Science (New York, N.Y.) · 1948
via PubMed
Wikidata facts
- Image
- Beta Glucuronidase Dimer.jpg
Show 1 more fact
- EC enzyme number
- 3.2.1.31
via Wikidata · CC0
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Encyclopedic overview
8 sectionsContents
- Structure
- Mechanism of catalysis
- Sly syndrome
- Use as a reporter gene
- See also
- References
- Further reading
- External links
β-Glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates. Human β-glucuronidase is a type of glucuronidase (a member of glycosidase Family 2) that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides (also referred to as glycosaminoglycans) such as heparan sulfate. Human β-glucuronidase is located in the lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present in breast milk, which contributes to neonatal jaundice. The protein is encoded by the GUSB gene in humans and by the uidA gene in bacteria.
== Structure == Human β-glucuronidase is synthesized as an 80 kDa monomer (653 amino acids) before proteolysis removes 18 amino acids from the C-terminal end to form a 78 kDa monomer. β-Glucuronidase exists as a 332 kDa homotetramer. β-Glucuronidase contains several notable structural formations, including a type of β-barrel known as a jelly roll barrel and a TIM barrel.
Excerpted from Wikipedia’s “beta-glucuronidase” article, available under the CC BY-SA 4.0 licence.