parathyroid hormone

Also known as parathyroid hormone 1, parathormone, parathyrin, PTH, preproparathyroid hormone, prepro-PTH

mammalian protein found in Homo sapiens

OverviewAI-generated

Parathyroid hormone is a human hormone encoded by the PTH gene. The protein has a length of 115 amino acids and a mass of 12861. Its structural and functional characteristics include a 3D-structure, cleavage on a pair of basic residues, and direct protein sequencing. The protein is classified as a hormone and has documented disease variants. Evidence for its existence is established at the protein level.

The entry for this hormone is reviewed and associated with the UniProt accession P01270. It is referenced by 339 other encyclopedia articles. ClinicalTrials.gov lists 787 studies related to parathyroid hormone.

Synthesized by Vinony from 15 facts across 4 sources: Wikidata, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Protein · UniProt

Parathyroid hormone

Gene: PTH
Organism: Homo sapiens (Human)
Length: 115 aa
Molecular mass: 12,861 Da
Evidence: 1: Evidence at protein level

Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed:11604398, PubMed:35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:18375760, PubMed:35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed:21076856)

3D-structureCleavage on pair of basic residuesDirect protein sequencingDisease variantHormoneProteomics identificationReference proteomeSecreted

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

787 registered

UNKNOWN
The Effect of Parathyroidectomy on Renal Function, Endothelial Function, and Blood PressureUniversitaire Ziekenhuizen KU Leuven · NCT00452049
NACOMPLETED
Bone Architectural Parameters in Postmenopausal Women Affected With Primary HyperparathyroidismAssistance Publique - Hôpitaux de Paris · NCT02539498
RECRUITING
Natural History Study of Parathyroid DisordersNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT04969926
PHASE4RECRUITING
Calcitonin Pre-treatment to Improve SPECT-CT SensitivityJoseph Sferra · NCT03935984
COMPLETED
IOPTH Usefulness for Predicting Successful Surgery in Secondary HyperparathyroidismHospital General Ajusco Medio · NCT04484116
PHASE1/PHASE2TERMINATED
Cinacalcet to Treat Hypercalcemia in Renal Transplant RecipientsMontefiore Medical Center · NCT00415584

via ClinicalTrials.gov

~15 min read

Encyclopedic overview

Identifiers AliasesPTH, PTH1, parathyroid hormone, Parathyroid hormone, FIH1 External IDsOMIM: 168450; MGI: 97799; HomoloGene: 266; GeneCards: PTH; OMA:PTH - orthologs

More reference expression data

Excerpted from Wikipedia’s “parathyroid hormone” article, available under the CC BY-SA 4.0 licence.