vitamin D receptor
Sign in to saveAlso known as vitamin D nuclear receptor variant 1, protein phosphatase 1, regulatory subunit 163, 1,25-dihydroxyvitamin D3 receptor, vitamin D (1,25- dihydroxyvitamin D3) receptor, VDR, Calcitriol Receptor, vitamin D3 receptor, Calcitriol Receptors
mammalian protein found in Homo sapiens
Protein · UniProt
Vitamin D3 receptor
- Gene
- VDR
- Organism
- Homo sapiens (Human)
- Length
- 427 aa
- Molecular mass
- 48,289 Da
- Evidence
- 1: Evidence at protein level
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid …
Swiss-Prot (reviewed) · via UniProt
Research
14,007 papers- Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021
- Vitamin D and its receptor polymorphisms are associated with glaucoma.Journal francais d'ophtalmologie · 2020
- Vitamin D Receptor Influences Intestinal Barriers in Health and Disease.Cells · 2022
- Vitamin D receptor polymorphisms and the susceptibility of Parkinson's disease.Neuroscience letters · 2019
- An Update on Vitamin D Metabolism.International journal of molecular sciences · 2020
via PubMed
Clinical Trials
75 registered- PHASE2UNKNOWNEvaluation of the High Dose Vitamin D3 Supplementation Effect and Influence of Polymorphism VDR Gene on Oxidative Stress and Inflammatory Process in ElderlyFederal University of Paraíba · NCT02222649
- TERMINATEDUltraviolet Light Exposure and Immunosuppression in Cutaneous MelanomaNew Mexico Cancer Research Alliance · NCT00996827
- NACOMPLETEDThe VALIDATE-D StudyBrigham and Women's Hospital · NCT01635062
- NACOMPLETEDEffects of Vitamin D Supplementation on Obesity, Inflammatory and Metabolic MarkersTirang R. Neyestani, Ph.D. · NCT05376865
- PHASE1COMPLETEDEfficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D RespondersUniversity of Eastern Finland · NCT03537027
- NAENROLLING_BY_INVITATIONThe Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic ConjunctivitisChina Medical University Hospital · NCT05839938
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P11473
- physically interacts with
- tacalcitol
via Wikidata · CC0