protocadherin
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Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family. The PCR fragments that corresponded to protocadherins were found in vertebrate and invertebrate species. This prevalence in a wide range of species suggested that the fragments were part of an ancient cadherin and were thus termed "Protocadherins" as the "first cadherins". Of the approximately 70 Pcdh genes identified in mammalian genomes, over 50 are located in
Research
1,703 papers- Protocadherin 19 Clustering Epilepsy and Neurosteroids: Opportunities for Intervention.International journal of molecular sciences · 2021
- Protocadherin-1 is essential for cell entry by New World hantaviruses.Nature · 2018
- Protocadherin 7-Associated Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2021
- PCDH19-Related Epilepsy Syndrome: A Comprehensive Clinical Review.Pediatric neurology · 2020
- New 'Antigens' in Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2021
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Article
7 sectionsContents
- Classification
- Function
- Homophilic interactions and intracellular signaling
- Human genes
- See also
- References
- Further reading
Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family. The PCR fragments that corresponded to protocadherins were found in vertebrate and invertebrate species. This prevalence in a wide range of species suggested that the fragments were part of an ancient cadherin and were thus termed "Protocadherins" as the "first cadherins". Of the approximately 70 Pcdh genes identified in mammalian genomes, over 50 are located in tightly linked gene clusters on the same chromosome. Until recently, it was assumed that this kind of organization can only be found in vertebrates, but Octopus bimaculoides has 168 genes of which nearly three-quarters are found in tandem clusters with the two largest clusters compromising 31 and 17 genes, respectively.
== Classification ==