PCDHB11
Sign in to saveAlso known as ME2, PCDH-BETA11, protocadherin beta 11
Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.
Gene data
PCDHB11- Name
- protocadherin beta 11
- Type
- protein-coding
- Position
- 141,199,610–141,203,779 (+)
- Aliases
- ME2, PCDH-BETA11
- Ensembl
- ENSG00000197479
- RefSeq RNA
- NM_018931.3
- RefSeq protein
- NP_061754.1
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
protocadherin beta 11
- Symbol
- PCDHB11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:141,199,610-141,203,779
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 134302
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/56125
- expressed in
- right coronary artery
- chromosome
- human chromosome 5
- genomic start
- 141199610
- genomic end
- 140582618
- cytogenetic location
- 5q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Excerpted from Wikipedia’s “PCDHB11” article, available under the CC BY-SA 4.0 licence.