PDCD4
Sign in to saveAlso known as H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
Gen der Spezies Homo sapiens
Gene data
PDCD4- Name
- programmed cell death 4
- Type
- protein-coding
- Position
- 110,871,790–110,900,013 (+)
- Aliases
- H731
- Ensembl
- ENSG00000150593
- RefSeq RNA
- NM_001199492.2, NM_014456.5, NM_145341.4
- RefSeq protein
- NP_001186421.1, NP_055271.2, NP_663314.1
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology
Biological process
apoptotic processBMP signaling pathwaynegative regulation of JUN kinase activitynegative regulation of DNA-templated transcriptionnegative regulation of DNA-templated transcriptionnegative regulation of DNA-templated transcriptionpositive regulation of inflammatory responsepositive regulation of inflammatory response
Molecular function
Pathways
Proteoglycans in cancer - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Cytokine Signaling in Immune systemImmune SystemInterleukin-12 family signalingSignaling by InterleukinsGene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationInterleukin-12 signalingTranslation inhibitors in chronically activated PDGFRA cellsInterferon type I signaling pathways
via MyGene.info
Gene · Ensembl
programmed cell death 4
- Symbol
- PDCD4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:110,871,790-110,900,013
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PDCD4 PDB 2ggf.png
Show 7 more facts
- HomoloGene ID
- 7879
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27250
- genomic end
- 112659764
- genomic start
- 112631565
- chromosome
- human chromosome 10
- cytogenetic location
- 10q25.2
Sources (3)
via Wikidata · CC0