EIF4A1
Sign in to saveAlso known as DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I, eukaryotic translation initiation factor 4A1
Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of prot
Gene data
EIF4A1- Name
- eukaryotic translation initiation factor 4A1
- Type
- protein-coding
- Position
- 7,572,718–7,579,007 (+)
- Aliases
- DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
- Ensembl
- ENSG00000161960
- RefSeq RNA
- NM_001204510.2, NM_001416.4
- RefSeq protein
- NP_001191439.1, NP_001407.1
Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 4A1
- Symbol
- EIF4A1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:7,572,718-7,579,007
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~10 min read
Encyclopedic overview
10 sectionsContents
- Background
- Structure
- Function
- Regulation
- Role in Disease
- Cancer
- Viral Infections
- References
- Further reading
- External links
Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-dependant RNA helicases, and plays a critical role in the initiation of cap-dependent eukaryotic protein translation as a component of the eIF4F translation initiation complex. eIF4A1 unwinds the secondary structure of RNA within the 5'-UTR of mRNA, a critical step necessary for the recruitment of the 43S preinitiation complex, and thus the translation of protein in eukaryotes. It was first characterized in 1982 by Grifo, et al., who purified it from rabbit reticulocyte lysate.
== Background ==
Excerpted from Wikipedia’s “EIF4A1” article, available under the CC BY-SA 4.0 licence.