PHC2
Sign in to saveAlso known as EDR2, HPH2, PH2, polyhomeotic homolog 2
Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.
Gene data
PHC2- Name
- polyhomeotic homolog 2
- Type
- protein-coding
- Position
- 33,321,755–33,431,095 (−)
- Aliases
- EDR2, HPH2, PH2
- Ensembl
- ENSG00000134686
- RefSeq RNA
- NM_001330488.2, NM_001385109.1, NM_001385112.1, NM_001385119.1, NM_001385120.1
- RefSeq protein
- NP_001317417.1, NP_001372038.1, NP_001372041.1, NP_001372048.1, NP_001372049.1
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
polyhomeotic homolog 2
- Symbol
- PHC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:33,321,755-33,431,095
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 75090
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1912
- genomic start
- 33789224
- chromosome
- human chromosome 1
- genomic end
- 33896653
- cytogenetic location
- 1p35.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.
== Function ==
Excerpted from Wikipedia’s “PHC2” article, available under the CC BY-SA 4.0 licence.