MAPKAPK2
Sign in to saveAlso known as MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.
Gene data
MAPKAPK2- Name
- MAPK activated protein kinase 2
- Type
- protein-coding
- Position
- 206,684,871–206,734,284 (+)
- Aliases
- MAPKAP-K2, MK-2, MK2
- Ensembl
- ENSG00000162889
- RefSeq RNA
- NM_004759.5, NM_032960.4, XM_005273353.4, XM_017002810.2, XM_047434418.1
- RefSeq protein
- NP_004750.1, NP_116584.2, XP_005273410.1, XP_016858299.1, XP_047290374.1
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
MAPK activated protein kinase 2
- Symbol
- MAPKAPK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:206,684,871-206,734,284
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MAPKAPK2 PDB 1kwp.png
Show 8 more facts
- HomoloGene ID
- 56412
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9261
- chromosome
- human chromosome 1
- genomic start
- 206684905
- genomic end
- 206734281
- cytogenetic location
- 1q32.1
- expressed in
- islet of Langerhans
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Function
- Vascular barrier
- SASP initiation
- See also
- Interactions
- References
- Further reading
MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.
== Function ==
Excerpted from Wikipedia’s “MAPKAPK2” article, available under the CC BY-SA 4.0 licence.