Plectasin
Sign in to savePlectasin is an antibiotic protein from the mushroom Pseudoplectania nigrella. It was initially discovered in 2005 and commercialised by Novozymes. Plectasin belongs to the antimicrobial peptide class called fungal defensins, which is also present in invertebrates such as flies and mussels.
In the Vinony graph
Within Vinony's link graph, Plectasin is referenced by 4 other articles, and connects out to bacteria, antibiotic and invertebrate.
It is catalogued under topics including Antibiotics, Defensins and Peptides.
Its subject is documented across 4 Wikipedia language editions.
Protein · UniProt
Fungal defensin plectasin
- Gene
- DEF
- Organism
- Pseudoplectania nigrella (Ebony cup)
- Length
- 95 aa
- Molecular mass
- 10,254 Da
- Evidence
- 1: Evidence at protein level
Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). It does not disrupt cell membranes (PubMed:20508130). Is especially active against numerous clinical isolates of S.pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292). In vitro, shows considerable selectivity for …
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
- Image
- Plectasin 3E7R.png
Show 1 more fact
- found in taxon
- Pseudoplectania nigrella
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Clinical trials
- References
Plectasin is an antibiotic protein from the mushroom Pseudoplectania nigrella. It was initially discovered in 2005 and commercialised by Novozymes. Plectasin belongs to the antimicrobial peptide class called fungal defensins, which is also present in invertebrates such as flies and mussels.
== Clinical trials == Pre-clinical tests in mice have shown promising results in that multiresistant bacteria have problems mutating resistance against plectasin, which acts by directly binding the bacterial cell-wall precursor Lipid II in a supramolecular complex.
Excerpted from Wikipedia’s “Plectasin” article, available under the CC BY-SA 4.0 licence.